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Circulating blood as an organ at risk: a dynamic framework for dose calculation during advanced radiation therapy

The latter part of Research Project 1.3 requires spatiotemporal simulations involving the dynamics of the beam delivery and anatomical motion. Research Project 1.4: Circulating blood as an organ at risk: a dynamic framework for dose calculation during advanced radiation therapy will implement even more elaborated patient models in the time domain, which are particularly relevant for studying dose-rate effects in patients.

This project focuses on the integral dose to circulating lymphocytes, which are highly radiosensitive and have been largely neglected as organ-at-risk in the past. Thus, a further novel feature of Research Project 1.4 is the optimization of treatment plans in the time domain considering the patient's blood circulation. The impact of the temporal and spatial dose patterns will be investigated across three configurations: conventional fluence-modulated PT fields, proton arc configurations, and proton shoot-through fields. Shoot-through fields allow for proton radiography to establish a direct link to Research Project 1.1.

Brain tumor from a CT scan © Abdelkhalek Hammi​/​TU Dortmund