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Sensitizers

The aim of this task area is to improve the understanding of sensitizers for PT, in particular the impact of their design and functionality, but also the mechanisms explaining the observed sensitization. The research projects address studies on how the surface composition of Pt nanoparticles affects the generation of ROS by catalytic water splitting reactions and also the question of how specific features of surface ligands influence the generation of ROS in proton-irradiated nanoparticles. Furthermore, they study the identification of appropriate ROS probe compounds formed when aqueous and NP-doped phantoms are irradiated with protons and assess the potential of Gd-contrast agents for theragnostics in the context of PT. The clinical relevance of the expected results is a significantly better understanding of sensitizers that will ultimately lead to improved tumor control and a more effective treatment routine.